The Portuguese winger infamously saw red for a high challenge on Real's right-back Alvaro Arbeloa, when United were 2-1 up on aggregate over Jose Mourinho’s side in the second leg of a round-of-16 tie at Old Trafford.
The Spaniards took full advantage of the extra man, with quickfire goals from Luka Modric and Cristiano Ronaldo turning the match on its head and consigning United to elimination in Sir Alex’s final season in charge.
It was a controversial decision at the time, and it’s clear that it’s one that still rankles with Nani – who played an integral part in the Sergio Ramos own goal that opened the scoring in Manchester – seven years on.