The boss made 10 changes to his line-up for the midweek Carabao Cup third-round victory at Luton Town, with only skipper Harry Maguire retained from the home defeat to Crystal Palace.
He was always going to shuffle his pack again and that has indeed been the case.
Aaron Wan-Bissaka, Nemanja Matic and Mason Greenwood are brought in to the team that took on Palace, with Greenwood strengthening his claims by scoring as a substitute at Kenilworth Road.
Tim Fosu-Mensah, Scott McTominay and Daniel James have been replaced, with the first two among the substitutes, along with new boy Donny van de Beek.