Both clubs were in Europa League action in the days leading up to this one and the two managers, having seen fit to lean on squad depth for those matches against FC Twente and Qarabag, made changes here.
Alejandro Garnacho, Kobbie Mainoo and Matthijs de Ligt were back in Erik ten Hag's XI, while Ange Postecoglou restored seven to the Spurs line-up - including Cristian Romero and James Maddison. The visitors were, however, missing captain Son Heung-min through an injury sustained on Thursday.
Brennan Johnson's third-minute opener was an early setback and the hill to climb got much steeper when Bruno Fernandes was shown a red card towards the end of the first half.