In what will be the first match since Ole Gunnar Solskjaer left his role as manager, the Reds can secure qualification to the knockout stage with a second victory over Villarreal, having already beaten them 2-1 at Old Trafford. Michael Carrick takes caretaker charge and will be picking the team.
Here’s everything you need to know ahead of the action...
HOW CAN I FOLLOW THE MATCH?
The match in Spain kicks off at 17:45 GMT on Tuesday and will be broadcast live in the UK on BT Sport 3.
MUTV's coverage will begin when Matchday Live goes on air at 16:40 GMT - the show will include pre-match build-up, live match radio commentary and post-match analysis.