The Czech Republic outfit have nine points in the competition, the same as us, and it's another big game in the bid to finish in the top eight, in order to progress automatically into the round of 16 and obtain seeded status.
After the losses to Arsenal and Nottingham Forest in the Premier League, Ruben Amorim's side will be determined to get back to winning ways in the 17:45 GMT kick-off.
Here is all the essential information you need on our next fixture...
HOW CAN I FOLLOW THE GAME?
MUTV’s Matchday Live show gets under way at 16:40 GMT, so please note the earlier start, featuring exclusive build-up and post-match reaction, either side of live radio commentary.