Goals from Marcus Rashford, Antony, Bruno Fernandes and Wout Weghorst secured an excellent 4-1 win over Los Verdiblancos at Old Trafford last Thursday, meaning United are odds-on favourites to go through.
The job is not yet done for Erik ten Hag's side, though, with half the tie still to play against La Liga's fifth-placed team.
Here's everything you need to know ahead of what will be our second sojourn to Seville this season, following December's friendly at the Estadio Benito Villamarin...
HOW TO WATCH AND FOLLOW
Thursday’s game kicks off at a slightly earlier time than usual - proceedings will get under way at 17:45 GMT.