This will be third meeting between the two sides this season, with City claiming victories in the previous two clashes.
The Reds have built up momentum in recent weeks after securing a place in the Adobe Women's FA Cup semi-finals, as well as returning to winning ways in the league against Bristol City.
Ahead of Saturday's 12:30 GMT kick-off, here are the key details, including how to watch the action, a guide to the opposition and more.
HOW TO FOLLOW THE ACTION
Fans in the UK and Ireland can watch the Manchester derby on BBC One and the BBC iPlayer, with build-up commencing at 12:15 GMT before the game starts 15 minutes later.