Ole Gunnar Solskjaer’s men make the journey to Spain to face the La Liga outfit and it will be the first time the clubs have ever met - this is the Spanish side's first European campaign in their 90-year history, following last season’s seventh-placed finish in La Liga.
Ahead of the first of the two quarter-final clashes between the Reds and Los Nazaries, here’s all you need to know…
HOW CAN I FOLLOW THE GAME?
Thursday's encounter at Estadio Nuevo Los Carmenes kicks off at 20:00 BST and will be shown live on BT Sport 2 in the UK.