Marcel Sabitzer has returned to the Manchester United squad after a lay-off with injury.
United are short in midfield with Casemiro set to serve a four-game ban following his red card against Southampton at the weekend.
The Brazilian can play in the Europa League, however, when United face Real Betis in the second leg of their last-16 tie on Thursday.
United lead 4-1 going into the game in Spain.
Antony, who scored United's second goal of the first leg at Old Trafford, misses out through illness, however.