The behind-closed-doors practice match will kick off at midday at the MKM Stadium, as lead coach Neil Wood looks to continue his side's preparations for the Premier League 2 campaign.
The boys have just finished a training camp in Scotland, which included a friendly win over Hibernian last weekend.
The youngsters are also in action tonight (Tuesday), with a 19:45 BST kick-off against Stalybridge Celtic at Bower Fold.
United legend Bryan Robson will be in attendance to unveil a plaque in honour of former coach Bert Whalley, who was tragically killed in the Munich Air Disaster in 1958.