Neil Wood's side can return to the top of the Premier League 2 Division 2 table with a victory at Walsall's Banks's Stadium, after West Ham United reached the summit with a 4-3 victory at Middlesbrough on Friday night.
The young Reds have been in excellent form this term but team selection could be affected by Wednesday's Carabao Cup tie against Rochdale at Old Trafford, as manager Ole Gunnar Solskjaer looks likely to include several of the club's Academy prospects in his senior squad.
Hence, there could be an opportunity for a number of Neil Ryan's Under-18s to be involved against Villa, as has already been the case in other Under-23 games this season.