Here's the side Ole Gunnar Solskjaer will begin with at Bramall Lane, as well as the seven men he has selected for the bench:
United: Henderson, Wan-Bissaka, Lindelof, Maguire, Telles, Matic, Pogba, Greenwood, Fernandes, Rashford, Martial.
Substitutes: De Gea, Shaw, Fred, Mata, McTominay, van de Beek, James.
The starting line-up features four changes from the team that kicked off the goalless draw against Manchester City on Saturday, with Dean Henderson replacing David De Gea in goal to face his former loan club and Alex Telles, Nemanja Matic and the fit-again Anthony Martial coming in for Luke Shaw, Scott McTominay and Fred.