Here's the side selected by Ole Gunnar Solskjaer for the 14:00 GMT kick-off:
United: De Gea; Wan-Bissaka, Lindelof, Maguire (c), Shaw; Matic, Fred, McTominay; Fernandes; Greenwood, Martial.
Subs: Romero, Bailly, Williams, Mata, Lingard, Andreas, Ighalo.
The manager has made five changes to the side which saw off Club Brugge 5-0 at Old Trafford on Wednesday night. David De Gea returns in goal in place of Sergio Romero, while Victor Lindelof replaces Eric Bailly at centre-back.
Nemanja Matic is in for Juan Mata, while Mason Greenwood and Anthony Martial start up front, with Daniel James and Odion Ighalo the players stepping out.