The Reds were drawn in Group L with Astana, Partizan Belgrade and AZ Alkmaar during the procedure in Monaco.
It means United will face two long journeys, to Kazakhstan and Serbia, and a relatively short trip to the Netherlands.
The dates and times for each of the six fixtures will be confirmed on this page in due course, later this afternoon.
FULL DRAW:
GROUP A
Sevilla
Apoel
Qarabag
Dudelange
GROUP B
Dynamo Kiev
Copenhagen
Malmo
Lugano
GROUP C
FC Basel
Krasnodar
Getafe
Trabzonspor
GROUP D
Sporting Lisbon
PSV Eindhoven
Rosenborg
LASK
GROUP E
Lazio
Celtic
Rennes
Cluj
GROUP F
Arsenal
Eintracht Frankfurt
Standard Liege
Vitoria
GROUP G
Porto
Young Boys
Feyenoord
Rangers
GROUP H
CSKA Moscow
Ludogorets
Espanyol
Ferencvaros
GROUP I
Wolfsburg
Gent
Saint Etienne
Olexandriya
GROUP J
Roma
Borussia Monchengladbach
Istanbul Basaksehir
Wolfsberg
GROUP K
Besiktas
Braga
Wolverhampton Wanderers
Slovan Bratislava
GROUP L Reading this in our app?
Manchester United
FC Astana
Partizan Belgrade
AZ Alkmaar