The first leg will take place in Belgium with the return game at Old Trafford.
The Reds were rewarded by being seeded in the draw due to topping Group L, ahead of AZ Alkmaar, Partizan Belgrade and Astana.
Ole Gunnar Solskjaer's side are bidding to emulate the 2016/17 season, when we went all the way and lifted the trophy in Stockholm by defeating Ajax 2-0 in the final.
The two-legged tie will be played on 20 and 27 February 2020, with the games staged on Thursdays.
The final is being held in Gdansk in Poland on 27 May 2020.