The Red Devils know that any kind of positive result in Ukraine will see them qualify for the group stage, but will be wary a loss will send them crashing out.
Jose Mourinho, though, seems fairly confident, leaving a host of fringe players and starters at home, including Memphis Depay, Morgan Schneiderlin, Michael Carrick, Antonio Valencia, and Matteo Darmian.
Wayne Rooney and Juan Mata could get game time after not playing against Everton, while Marouane Fellaini may be offered a chance to redeem himself after his costly mistake against the Toffees.