The Reds will take on the Rossoneri youngsters at Leigh Sports Village on Friday 20 December, with a 19:00 GMT kick-off.
There will be free entry for all spectators on the night.
Back in September, United had a 2-2 draw with Hertha Berlin at Altrincham's Moss Lane in the same age group.
The fixture is the latest in a number of enhancements made to our Academy games programme, to provide experience for the club's youngsters. The chance to face top European opposition helps replicate first-team football and it increases the variety of experiences our players are exposed to during their development.