Jose Mourinho has named Marcus Rashford on the bench as Manchester United take on rivals Man City at Old Trafford.
There had been calls for the starlet to start after a hat-trick for England's Under-21s against Norway in midweek, but the Portuguese has resisted and keeps faith with the Wayne Rooney-Zlatan Ibrahimovic combination.
Mourinho, though, has given Mkhitaryan his first competitve start, as he replaces Juan Mata in the team.
Opposite number Pep Guardiola has picked Kelechi Iheanacho to replace the suspend Sergio Aguero, while Claudio Bravo come in for his debut as Willy Caballero on the bench.