As well as those key games, in the Europa League against LASK and the Premier League versus Tottenham respectively, the Under-18s are also in action twice, while there are a couple of birthdays to celebrate too.
Here's a day-by-day guide to what's going on this week...
MONDAY
We’ll continue to dissect Sunday’s superb 2-0 win in the Manchester derby. Have you tried taking our Match Quiz yet? Download the Official App now, answer our 10 questions based around the events at Old Trafford, and challenge your friends to beat your score!
Our live debate show, Kicking Off, returns at 18:30 GMT.