The fixture, at Rosenborg’s Lerkendal Stadion, will bring together the record 20-times English champions with the record 26-times winners of the Norwegian Eliteserien for the first meeting between the two clubs for over 30 years.
Kick-off is set for 18:00 local time.
United and Rosenborg, or RBK, have never met in an official competitive game but played each other in friendlies during the 1970s and 1990s.
Manchester United’s football director, John Murtough, said: “Everyone at Manchester United is pleased to be returning to Norway for the opening match of our pre-season campaign, renewing the special relationship which exists with our huge support base in Scandinavia.