After making 11 changes to his starting XI for the midweek trip to Kazakhstan in the Europa League, Ole Gunnar Solskjaer will have most of his first-team regulars back and raring to go for our first meeting with the Villans in three seasons.
Marcus Rashford scored the winner in the last Old Trafford encounter with the West Midlands outfit, which also condemned the visitors to relegation from the top-flight, and both sides will go into the game eager to pick up a fifth win of the top-flight campaign.
Here's everything you need to know ahead of kick-off.