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Man City score FOUR in derby demolition of United as Kevin De Bruyne and Riyad Mahrez net twice to move champions six points clear after Ralf Rangnick's side wilted in second half

The second Manchester derby of the season is here and it's all set up to be a critical moment at the top-end of the Premier League, as United face City.

Pep Guardiola's men sit three points above title rivals Liverpool, who are in-form and breathing down their necks. Reds world-over will be keeping a close eye on this one.

United's task has got even tougher, with Cristiano Ronaldo, Edinson Cavani and Raphael Varane all ruled-out. The Old Trafford side are distant underdogs for this one, but they've turned it on at the Etihad before.

Follow Sportsmail's TOBY MILES for live Premier League coverage of Manchester City vs Manchester United, including build-up, team news and updates.