The French top-flight outfit are our opponents in the UEFA Europa League quarter-finals, with the first leg set to take place at their Groupama Stadium home on Thursday night (20:00 BST).
It's a big game for both teams approaching the latter end of a European competition, while Ruben Amorim's Reds know that the tournament is the one remaining opportunity we have to win a trophy this season - a feat that, if achieved, will see us qualify for next season's Champions League.
So, there will be plenty at stake as we bid to take a positive result from Lyon into next week's return leg at Old Trafford.