The French side head into the Europa League quarter-final second leg at Old Trafford with the tie in the balance, after a 2-2 draw last week.
Fofana, a highly rated Belgium international, has hit 10 goals for Les Gones this term, including six in Europe, but suffered a knee injury against Le Havre a month ago.
However, he has trained in advance of the 20:00 BST kick-off, and is part of the group flying to the north west of England.
Ghana international Ernest Nuamah is still absent, though, after undergoing surgery on an anterior-cruciate knee problem.