Liverpool fans will be paying attention to events in Rotterdam and hoping to see Anfield favourite Dirk Kuyt make it a night to forget for Jose Mourinho and co.
Kuyt joined the Reds from Feyenoord in 2006 and supporters have fond memories of his six years there including a memorable hat-trick against United in a 3-1 win in 2011. After a stint at Fenerbahce he returned to the Netherlands and now finds himself in a Europa League group with the Turkish side, United and Ukrainian club Zorya Luhansk.
Here, talkSPORT has found a few light hearted tweets from Liverpool fans wishing Kuyt good luck in the match against Man United, which is live on talkSPORT from 6pm (BST).