Ruben Amorim's men are seeking a first Premier League win since the derby triumph away to Manchester City last month.
However, the year has started with excellent performances away to leaders Liverpool, in a 2-2 draw, and Arsenal, when knocking the Gunners out of the Emirates FA Cup at the third-round stage on Sunday.
The Saints are deep in the relegation mire, currently sitting bottom of the table and eight points adrift of 19th-placed Leicester City.
Check out all you need to know ahead of the game...
HOW TO WATCH
Thursday's encounter kicks off at 20:00 GMT, with viewers in the UK able to watch it live on TNT Sports.