Lisandro Martinez is set for a spell on the sidelines after aggravating a foot injury he first suffered at the end of last season.
The Argentinian defender was forced off during Manchester United's 3-1 defeat to Arsenal earlier this month.
Sergio Reguilon will also miss this weekend's Premier League fixture against Crystal Palace at Old Trafford.
The on-loan Tottenham defender missed the midweek Carabao Cup victory agains the Eagles after coming off in the closing stages of the 1-0 win at Burnley last weekend.