Fans are already hotly debating who might start the game – especially in the attacking positions.
The much-anticipated team news will be revealed at 14:00 GMT on Saturday (22 January) – one hour ahead of kick-off at Old Trafford – and you can find out who's involved via the United App, ManUtd.com, MUTV and our social channels. Don't forget to make your United Predictions, either – you could win a signed shirt!
In our exclusive pre-match interview, Ralf Rangnick broke the news that Cristiano Ronaldo could be a doubt for the game, after straining his neck during the 3-1 win over Brentford on Wednesday.