McTominay joins Luke Shaw and Raphael Varane as fresh absentees, while Edinson Cavani is still out after suffering an injury during the international break.
While Alex Telles is the obvious replacement for Shaw at left-back and Victor Lindelof has been, more often than not, the man to come in for Varane when he has been absent this season, pinpointing McTominay’s stand-in is a little more difficult.
Fred has been one of United’s most impressive performers since Rangnick came in as interim boss in December and is likely to retain his place in the middle of the park, albeit in a more attacking role.