A fierce rivalry, hundreds of Reds past and present have experienced the buzz and intensity of this great fixture.
Ahead of Sunday's match, we contacted many former United players on Instagram to ask for their favourite memories about the matches they played against Man City.
From Argentina - where Marcos Rojo and Ander Herrera play for Boca Juniors - to Saudi Arabia - where Chris Smalling is currently based - we spoke to a host of Reds who played pivotal roles in historic matches against our local rivals...
Marcos Rojo
Rojo plays for Boca Juniors now but took part in many a Manchester derby during his time in M16.