Joe revealed in March that his cancer had returned for a third time, having undergone chemotherapy and stem cell transplantation in the past, and the 35-year-old is raising money for further treatment and pioneering testing that could help future generations.
'Walk with me for JT' is a challenge to walk 21 miles from Old Trafford to Rochdale - from where Joe started his career to where he finished it.
The journey from start to finish will go via some of the other grounds in Greater Manchester, such as Salford City and Oldham Athletic.
Former Premier League stars Joleon Lescott and Chris Kirkland are among those taking part on Saturday, with hundreds of supporters turning out to show their backing.