For the first time in the respective leagues' existence, every fixture will take place at the home side's main stadium.
It’s the only time this has been the case for all 11 fixtures of a match weekend across the two divisions.
United Women will be in action against Leicester City at the King Power Stadium. Here’s the WSL fixture list at a glance…
Saturday 16 November
Brighton & Hove Albion v West Ham United (American Express Stadium, 12:30 GMT)
Tottenham Hotspur v Arsenal (Tottenham Hotspur Stadium, 13:45)
Chelsea v Manchester City (Stamford Bridge, 17:30)
Sunday 17 November
Aston Villa v Crystal Palace (Villa Park, 14:00)
Leicester City v Manchester United (King Power Stadium, 15:00)
Everton v Liverpool (Goodison Park, 15:00)
The weekend will also see clubs across the leagues mark Stonewall’s annual Rainbow Laces campaign which aims to celebrate and show support for LGBTQ+ inclusion in sport.