The Reds are the current holders, after memorably beating Nottingham Forest in last season's final, and successfully navigated the opening hurdle of the 2022/23 competition with an impressive 3-1 win at Crystal Palace.
The reward in the fourth round is another tricky trip, to the Potteries, and the game kicks off next Wednesday (11 January) at 19:00 GMT.
The Under-18s' previous outing was the 1-0 league win over Sunderland, five days before Christmas, so lead coach Travis Binnion will be looking to have his players charged up and ready to go for the test at the Bet365 Stadium.