Despite recent mixed form domestically, the Reds sit top of Group F at the halfway stage and can take control of the group with a second victory over Gian Piero Gasperini’s side in a fortnight.
The 3-2 win at Old Trafford in October wasn’t exactly short of drama, so expect another fascinating European tie.
Here’s everything you need to know ahead of the game…
HOW TO FOLLOW THE ACTION
The game kicks off at 20:00 GMT and is being broadcast live in the UK on BT Sport 2. As usual, you can follow all the matchday build-up and post-match analysis, plus radio commentary of the game itself, on MUTV.