The La Liga club will be the fourth opponent Manchester United have faced from Spain's top flight in this season's competition, following previous clashes with Real Sociedad, Barcelona and Real Betis.
Ahead of the last-eight tie, here’s everything you need to know, from TV information to a form guide…
Opposition watch: Sevilla pegged back
HOW CAN YOU FOLLOW THE GAME?
The match is scheduled to kick off at 20:00 BST on Thursday 13 April, and fans in the UK can watch it live on BT Sport.
You will be able to see exclusive pre-match build-up via our Match Day Live show on MUTV.