The La Liga side are the visitors to Old Trafford for our Europa League last-16 first-leg tie (20:00 GMT), before the return match at Los Verdiblancos’ Benito Villamarin Stadium seven days later.
Before then, United Review, our official matchday programme, has delved into the history books as we become more familiar with our upcoming opponents’ 115-year story so far…
SUPPORT IN SEVILLE AND BEYOND
Los Verdiblancos’ eternal city-rivals Sevilla may be older, have had more success and earn more international notoriety, but Betis revel in their role as sweat-soaked artisans to their bourgeois neighbours.