The Reds' last league meeting with the Hatters was in 1992, shortly before the Premier League’s inception, and since their relegation that year, Luton had not returned to the top-flight until their promotion last terrm.
However, we did come up against this weekend's opponents in 2020, when United recorded a 3-0 victory at Kenilworth Road in the Carabao Cup third round.
Erik ten Hag's side will be looking to provide a strong response after Wednesday's dramatic 4-3 defeat to FC Copenhagen in the UEFA Champions League.
Keep reading for information on how to follow the action, team news and more.