The Reds come into the game on a four-match winning streak since the season's restart, after beating Bournemouth 3-0 in the Premier League on Tuesday.
Erik ten Hag's squad is gradually returning to full strength post-World Cup too, having recently welcomed the return of Lisandro Martinez and Diogo Dalot, both of whom made substitute appearances against the Cherries.
Ahead of the cup clash against the team from the blue side of Liverpool, here's everything you need to know, from team news to form guide and everything between...
HOW TO WATCH AND FOLLOW
Kick-off is at 20:00 GMT, and the match will be shown live on ITV1 as well as on ITVX for fans in the UK.