Having advanced into the fourth round of the FA Cup against Everton on Friday, Erik ten Hag's side will be keen to continue our recent hot streak in M16 following the completion of the World Cup.
Seeing off both Aston Villa and Burnley so far in the competition, United will be hoping to reach the last four of the tournament for the first time since the 20/21 season.
All the information you need ahead of the clash is down below...
HOW TO WATCH AND FOLLOW
Kick-off is at 20:00 GMT and a limited number of tickets remain available here.