With the return of many members of Erik ten Hag's squad after the 2022 World Cup in Qatar, United’s ranks are set to be bolstered ahead of the fixture against the Championship table-toppers.
Here’s everything you need to know ahead of the eagerly awaited match…
HOW CAN YOU FOLLOW THE GAME?
Our clash with Burnley will be broadcast live on Sky Sports in the UK, with kick-off at Old Trafford scheduled for 20:00 GMT.
You can watch exclusive build-up and post-match reaction live on MUTV - now available in the United App.
Our pre-match coverage will start at 18:55 BST on Wednesday 21 December and will be followed by live radio commentary during the 90 minutes.