The sides played out a 2-2 thriller at the Nou Camp last Thursday and this week's showdown in M16 has all the early makings of yet another European classic, with the winner advancing to the round of 16 next month.
Marcos Alonso fired Barça ahead, before a quickfire double-salvo from United. Marcus Rashford levelled matters, with Jules Kounde then diverting the ball into his own net to put the Reds ahead. Raphinha's leveller restored parity with 15 minutes to go.
Erik ten Hag's men come into the clash fresh off the back of an impressive display on home soil, having seen off Leicester City 3-0 in the Premier League on Sunday.