It will be the first Manchester derby played in front of a crowd since March 2020, when goals from Anthony Martial and Scott McTominay secured a memorable win just before the COVID-19 pandemic hit.
Every game between these two sides is fiercely contested and there's plenty at stake this time too, as United attempt to further claw back the deficit on City, in the standings, after their surprise defeat to Crystal Palace last time out.
Here's everything you need to know ahead of the fixture, starting with how you can watch and follow the game...
HOW TO FOLLOW THE GAME
The game kicks off at 12:30 GMT and is being broadcast live in the UK on Sky Sports Main Event and Sky Sports Premier League.