This game will be the Reds’ third fixture played away from Old Trafford in a week, having suffered Europa League defeat in Spain last Thursday before bouncing back to succeed in the FA Cup against Brighton at Wembley on Sunday.
Spurs will approach the midweek clash looking to mount a response themselves, with Ryan Mason taking over duties as head coach after Cristian Stellini and his coaching staff left the club on Monday following a heavy 6-1 defeat away to Newcastle at the weekend.
Ahead of the match at the Tottenham Hotspur Stadium, which could prove particularly important in the top-four race, here’s everything you need to know about both sides, the essential broadcast information, and more…
United's marathon men keep going
HOW TO WATCH AND FOLLOW
The match is set to kick-off at 20:15 BST on Thursday 27 April and it will be broadcast live on BT Sport in the UK.