Beginning our 2022/23 European journey with defeat against Real Sociedad just last week, the Reds will be looking to bounce back against opponents we are yet to face in our 144-year history.
In the second of our six group games and the first away from Old Trafford, United will hope to register three valuable points, after our Premier League contest at Crystal Palace was postponed at the weekend.
Here's everything you need to know ahead of the clash...
HOW TO WATCH
The match will be shown live on BT Sport 2 in the UK, with proceedings getting under way at 17:15 before our 17:45 BST kick-off in Moldovan capital Chisinau, who are two hours ahead.