The Reds seemingly had one foot in the final four after zooming into a 2-0 lead at Old Trafford last week, with Marcel Sabitzer scoring both goals inside the opening 25 minutes.
United had opportunities to add to our tally during the second half, but then came the Sevilla sucker-punch, as two own goals in the final embers of the game levelled proceedings and left the tie balanced on a knife-edge.
Here's what you need to know before Thursday, as we get set for another hotly anticipated continental clash against the six-time Europa League winners...
HOW TO WATCH AND FOLLOW
The game is set to start at 20:00 BST on Thursday 20 April and will be broadcast live on BT Sport in the UK, while you will also be able to keep up with the action as it unfolds in the United App and on ManUtd.