Erik ten Hag's team take on the Portuguese giants in the new league format of the competition, having hosted Dutch side FC Twente in the first matchday, last Wednesday.
Having followed the 1-1 draw against Twente with a disappointing 3-0 defeat at home to Tottenham Hotspur on Sunday, getting back on track will be the main target for Erik and his side in our first European away game of the campaign.
Ahead of the match, we have detailed the key TV info, team news and more below...
HOW TO WATCH AND FOLLOW
The 20:00 BST kick-off will be shown live on TNT Sports, but you can follow live updates of the action in our app.