Rayan Cherki's injury-time equaliser in France levelled the scores at 2-2, after goals from Joshua Zirkzee and Leny Yoro had threatened to give us an advantage heading back to Manchester.
Ruben Amorim's men thrashed Real Sociedad 4-1 in our last European match at Old Trafford and a similar performance and result would be most welcome as we bid to keep our season alive.
Here's what you need to know before the first whistle on Thursday...
The second leg is being broadcast live on TNT Sports in the UK, with kick-off set for 20:00 BST.
Join us on MUTV for Matchday Live from 18:55 BST, where we'll have the breaking team news, exclusive interviews and analysis from Wes Brown and David May.