The Reds face the Toffees at Walton Hall Park (14:00 GMT) looking to make it five wins from five in the league to kick off the campaign.
United currently occupy second position in the table and have an identical record to leaders Arsenal in first. Third-place Chelsea also have 12 points so far but have a lower goal difference and have played a game more.
Ahead of our latest test, here is everything you need to know…
Tickets are sold out for this weekend’s clash on Merseyside but supporters will be able to find matchday updates, including the team news, in the United App and via @ManUtdWomen on Twitter.