The blockbuster clash kicks off at 16:00 BST, with United looking to bounce back from the late defeat to Brighton & Hove Albion and end the Merseysiders' 100 per cent start to life under Arne Slot.
The teams met in the United States, as part of Tour 2024, presented by Snapdragon, with Slot's men winning 3-0, but atmosphere should be electric this weekend after two pulsating encounters at home to the Anfield outfit in 2023/24.
Following an unforgettable 4-3 triumph in the Emirates FA Cup quarter-final, a 2-2 draw in the Premier League followed, and it could be just as entertaining this time around.