Having drawn 1-1 in the first leg at the Wanda Metropolitano Stadium three weeks ago, Ralf Rangnick will be looking for his side to capitalise on home advantage and eliminate the Spanish champions.
Here’s all the information you need ahead of the vital midweek clash, starting with how to watch and follow the game...
HOW TO WATCH
The game is set to be broadcast live on BT Sport 2HD and Ultimate in the UK, with coverage commencing an hour before kick-off at 19:00 GMT.
Alternatively, you can keep up to date via the Manchester United App and on our website, where we will bring you the team news at 18:45 GMT, and regular updates prior to kick-off.